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Grants Portfolio - Active Awards
AFTD-ADDF Accelerating Drug Discovery for FTD
Defining oligonucleotide therapeutics that reverse FUS proteinopathy
James Shorter, PhD, MA | University of Pennsylvania
2025
$350,000
A new therapeutic antibody for Frontotemporal Dementia
Chenxi Qiu, PhD | Beth Israel Deaconess Medical Center
2025
$349,590
Development of a granulin biologic to treat progranulin deficient FTD
Thomas Kukar, PhD | Emory University
2025
$349,890
Novel prolyl oligopeptidase ligands to target Tau in frontotemporal dementia and other tauopathies
Timo Myöhänen, PhD | Polku Therapeutics
2024
$282,600
Mitigating TDP-43 loss of function and disease initiation in FTD thru repair of the Nuclear Pore and CHMP7/ESCRT3 dysfunction
Jeffrey Rothstein, MD, PhD | Johns Hopkins School of Medicine
2023
$269,967
Selecting lead candidate REV-ERB agonist for the treatment of FTD
Robert Williams, PhD | Pelagos Pharmaceuticals
2022
$214,118
Discovery of selective LRP1 inhibitors to prevent tau uptake and spread
Kenneth Kosik, MD | University of California Santa Barbara
2020
$300,000
Development of PIKFYVE antisense oligonucleotides (ASO) treatment for FTD
Wen-Hsuan Chang, PhD | AcuraStem Inc.
2020
$165,000
Low Dose Lithium Treatment of Behavioral Complications in Alzheimer's Disease
Edward Huey, MD | Columbia University Medical Center
2015
$263,830
AFTD-ADDF Diagnostics Accelerator
Neurofilament (Nf) as a Fluid Biomarker of Neurodegeneration in Familial Frontotemporal Degeneration (f-FTD)
Rohini Khillan, PhD | Foundation for the National Institutes of Health (FNIH)
2021
$250,000
Plasma pathologic TDP-43 as a biomarker for FTLD-TDP
Qinwen Mao, MD, PhD | The University of Utah School of Medicine
2021
$500,000
Remote blood biomarker monitoring in frontotemporal lobar degeneration: Neurofilament Surveillance Project (NSP)
Laura Mitic, PhD | The Bluefield Project to Cure FTD
October 2019
$1,200,000
FTD Diagnostic Biomarkers Initiative (2025 onward)
TDP-43 cryptic targets in FTD
Leonard Petrucelli, PhD | Mayo Clinic, Jacksonville
2025
$700,000
Tau Citrullination in Biofluids as a Diagnsotic Biomarker for Tauopathies
Nicolas Barthélemy, PhD | Washington University
2025
$698,803
Detection of misfolded TDP-43 in FTD patient biofluids
Andrew Stern, MD, PhD | Brigham and Women’s Hospital
2025
$699,983
FTD Biomarkers Initiative (2016-2020)
Mapping neuroinflammation in frontotemporal lobar degeneration – development of a surrogate marker for early diagnosis and disease progression
Tammaryn Lashley, MD, PhD | UCL Institute of Neurology
2019
$1,102,133.19
Digital Assessment Tools for FTD and ALS
Harmonizing remote smartphone assessments of cognition, behavior, and motor functioning across the spectrum of FTD and ALS
Adam Staffaroni, PhD | UCSF
2023
$350,000
Digital Measurements of Motor and Voice Functions in FTD
Ashkan Vaziri, PhD | BioSensics
2023
$399,999
Treat FTD Fund
Open-label Clinical Trial of Nabilone for Neuropsychiatric Symptoms in Frontotemporal Dementia
Simon Ducharme, MD | McGill University
2021
$1,399,077.51
Non-Invasive Brain Stimulation for Gamma Induction and Cognitive Enhancement in FTD
Emiliano Santarnecchi, PhD | Harvard Medical School
2019
$1,959,841
Pilot Grants
PATHWAYS FOR HOPE
Multimodal contributions to white matter hyperintensities in behavioral variant frontotemporal dementia across diverse settings
Indira García Cordero, PhD | University of San Andrés
2024-2025
$109,025
PATHWAYS FOR HOPE
Leveraging a large GRN family to identify resilience factors in Frontotemporal Lobar Degeneration: a genetic and proteomic approach
Cyril Pottier, PhD | Washington University in St. Louis
2024-2025
$110,000
WELL-BEING IN FTD
Development of an Educational Support Group Program for Latino and Hispanic Caregivers of Individuals with Language-Prominent Dementia
Stephanie Grasso, PhD | University of Texas at Austin
2024-2025
$109,994
PATHWAYS FOR HOPE
Integrated proteomics and phosphoproteomics across FTLD-TDP subtypes
Zachary McEachin | Emory University
2023
$110,000
PATHWAYS FOR HOPE
Synthetic promoter screening to uncover determinants of FTD pathology
Zevik Melamed | Hebrew University of Jerusalem
2023
$110,000
WELL-BEING IN FTD
An ethical framework for disclosure of onset-predicting biomarkers in frontotemporal dementia
Eline Bunnik, PhD | Erasmus Medical Center
2023
$93,300
WELL-BEING IN FTD
Social Network Neuromodulation in Behavioral Variant Frontotemporal Dementia
Alexandru Iordan, PhD | University of Michigan
2022
$109,784
Ad Hoc Grants
Phillip Wong, PhD | Johns Hopkins University
2025
Dysregulated TDP-43 Biomarkers (with Alzheimer's Drug Discovery Foundation)
$640,000
Robin Riddle | Brain Support Network
2025
Brain Support Network Bridge Grant
$25,000
Olivier Piguet, PhD | International Society for Frontotemporal Dementias (ISFTD)
2023
ISFTD Infrastructure Grant
$250,000
Jonathan Rohrer, MD, PhD | University College London
2023
UK-GENFI Bridge Funding Grant (with Bluefield Project to Cure FTD)
$580,000
Clinical Research Training Scholarship in FTD
Investigating the molecular role of TMEM106B inclusions in C9ORF72- FTD/ALS
Janani Parameswaran, PhD | Emory University
2025
$150,000
Large-scale biofluid proteomics to identify disease progression biomarkers in C9orf72 frontotemporal dementia
Rowan Saloner, PhD | UCSF
2024
$150,000
Personalized HD-tDCS in Primary Progressive Aphasia
Tanav Popli, MD | University of Michigan
2023
$150,000
Holloway Postdoctoral Fellowships
Staging FTLD-tau by fluid tau biomarkers
Takumi Nakamura, MD, PhD | Washington University in St. Louis
2025
$120,000
Defining a role of mRNA methylation in FTD
Chang Liu, PhD | Stanford University
2025
$120,000
Determining the Impact of TMEM106B Fibrils on Neurons
John Replogle, PhD | National Institute of Neurological Disorders and Stroke (NIH/NINDS)
2024
$120,000
Frontotemporal Dementia (FTD) and the Criminal Legal System: An Examination of Experiences and Policies
Victoria Helmly, PhD | Georgia State University
2024
$120,000
Virtual Reality Social Cognition Game for Preclinical Frontotemporal Dementia
Jackie Poos | Erasmus Medical Center
July 2023
$115,123
Active AFTD Awards
Translational Research
AFTD-ADDF Accelerating Drug Discovery for FTD
AFTD-ADDF Diagnostic Accelerator
FTD Diagnostic Biomarkers Initiative
Digital Assessment Tools for FTD and ALS
Holloway Fellowships
Clinical Research Training Scholarship in FTD
Holloway Postdoctoral Fellowship
