For Researchers

Today’s research can lead to tomorrow’s breakthroughs. In this section, you’ll learn about research funding opportunities, new AFTD initiatives, and more.

Previous Grant Recipients

2017 Award Recipients

Treat FTD Fund

“Non-invasive brain stimulation to restore cortical plasticity and connectivity in genetic and sporadic FTD”
Barbara Borroni, MD
University of Brescia

Pilot Grants

Basic Science

“Accelerating tau pathogenesis in a new mouse model of frontotemporal dementia”
Todd Cohen, PhD
University of North Carolina at Chapel Hill

Susan Marcus Translational Research

“Ambulatory assessment of sleep disorders in FTD”
Haakon Nygaard, MD, PhD
University of British Columbia

AFTD Postdoctoral Fellowships

“Identification and validation of novel MAPT splicing factors and RNA-binding proteins”
Kathryn Bowles, PhD
Icahn School of Medicine at Mt. Sinai

“Nucleocytoplasmic transport defects perturb granular flux in FTD”
Joseph-Patrick Clarke, PhD
University of Pittsburgh

AFTD-ADDF Accelerating Drug Discovery for FTD

“Rescue of lysosomal dysfunction, neuroinflammation, and neurodegeneration by lysosomal GRN-2 in a mouse model of PGRN deficiency and Frontotemporal Dementia”
Thomas Kukar, PhD
Emory University

2016 Award Recipients

FTD Biomarkers Initiative

“Human CNS tau kinetics in tauopathies”
Randall Bateman, MD
Washington University in St. Louis

“sTREM2, PGRN and GRN as CSF markers for microglial activity, disease progression and therapeutic target engagement”
Christian Haass, PhD
Ludwig-Maximilians University and DZNE

“Assessing poly(GP) proteins as clinical and pharmacodynamic biomarkers of C9orf72-associated FTD”
Leonard Petrucelli, PhD
Mayo Clinic – Jacksonville

“Identification of novel biofluid markers of tau and TDP-43 pathology”
Jonathan Rohrer, MRCP, PhD
University College London

“Quantitative profiling of tau in CSF to pilot diagnoses and monitoring treatment effectiveness in FTD patients”
Judith Steen, PhD
Boston Children’s Hospital

“Using TDP43 as a biomarker in FTD patients”
Judith Steen, PhD
Boston Children’s Hospital

Pilot Grants

Basic Science

“Tau and adult neurogenesis. Therapeutic potential for frontotemporal degeneration”
María Llorens-Martín, PhD
Center for Networked Biomedical Research in Neurodegenerative Diseases

Susan Marcus Translational Research

“Detection of misfolded TDP-43 protein in CSF and plasma of GRN and C9ORF72 mutation carriers”
Paola Caroppo, MD, PhD
RCCS Foundation Carlo Besta Neurological Institute

AFTD-ADDF Accelerating Drug Discovery for FTD

“Mitochondrial TDP-43 as a Novel Therapeutic Target for FTD”
Xinglong Wang, PhD
Case Western Reserve University

“A novel neuroprotective compound targeting endogenous function of C9ORF72 in vivo”
Justin Ichida, PhD
University of Southern California

2015 Award Recipients

Pilot Grants

Basic Science

“Reducing repeat toxicity in iPSC cortical neurons of C9ORF72 FTD patients”
Sandra Almeida, PhD
University of Massachusetts Medical School

Susan Marcus Translational Research

“Transcranial direct current stimulation (tDCS) as a treatment for Primary Progressive Aphasia”
Roy Hamilton, MD
University of Pennsylvania

AFTD Postdoctoral Fellowships

“RNA dysfunction in Frontotemporal Dementia”
Hilary Archbold, PhD
University of Michigan

“Developing a tool for discriminating social cognition deficits in bvFTD from that of depression”
Maya Lichtenstein, MD
Geisinger Health System

AFTD-ADDF Accelerating Drug Discovery for FTD

“Quantitation of TDP-43 isoforms in CSF by mass spectroscopy”
Mari DeMarco, PhD
University of British Columbia 

“Low-dose lithium for the treatment of behavioral symptoms of FTD”
Edward Huey, MD
Columbia University

“The role of perfusion MRI in improving the diagnosis of FTD subtypes and longitudinal monitoring of disease progression”
Keith St. Lawrence, PhD
Lawson Health Research Institute

2014 Award Recipients

Pilot Grants

Basic Science

“Identification of the signaling receptor that mediates the neurotrophic activity of Progranulin (PGRN)”
Thomas Kukar, PhD
Emory University

Susan Marcus Translational Research

“RNA signatures of frontotemporal dementia and ALS due to C9ORF72 expansion”
Jennifer Yokoyama, PhD
UCSF

AFTD-ADDF Accelerating Drug Discovery for FTD

“Novel Diagnostic CSF Biomarkers for Pathological Subtypes of FTD”
Charlotte Teunissen, PhD
VU Medical Center in Amsterdam

“Lead Optimization and Pre-clinical Testing of Small Molecules that Modulate Toxicity of cFTD/ALS”
Matthew Disney, PhD
The Scripps Research Institute

2013 Award Recipients

Pilot Grant

“Internet-based speech therapy: Improving quality of life and access to care”
Emily Rogalski, PhD
Northwestern University

AFTD Postdoctoral Fellowship

“Chemical neurobiology of tauopathy patient iPSC-derived neurons”
Catarina Silva, PhD
Harvard University

AFTD-ADDF Accelerating Drug Discovery for FTD

“FTD C9ORF72 Based Biomarkers for Antisense-based Drug Discovery Validation”
Jeffrey Rothstein, MD, PhD
Johns Hopkins University 

“Brain slice screen for microRNA-targeted drug lead candidates for tau-associated FTD”
Donald Lo, PhD
Duke University

2012 Award Recipients

AFTD-ADDF Accelerating Drug Discovery for FTD

“Development of antisense therapy and therapeutic biomarker for C9orf72 FTD/ALS mutation patients”
Jeffrey Rothstein, MD, PhD
Johns Hopkins University

“Restoring progranulin in frontotemporal disease”
Nigel Cairns, FRCPath, PhD
Washington University, St. Louis

“Development of small molecule enhancers of autophagy for the clearance of protein aggregates and treatment of FTD”
Haung Yu, PhD
Columbia University

2011 Award Recipient

Pilot Grant

“Signaling mechanisms of progranulin”
Fenghua Hu, PhD
Cornell University

AFTD Postdoctoral Fellowship

“TMEM106B and related family members in progranulin biology”
Alexandra Nicholson, PhD
Mayo Clinic – Jacksonville

AFTD-ADDF Accelerating Drug Discovery for FTD

“Biomarker Optimization for Progranulin Trials”
Adam Boxer, MD, PhD
UCSF

“Dynamic disease-monitoring network biomarkers for tracking frontotemporal dementia”
William Seeley, MD
UCSF

“Identification of novel discriminatory CSF biomarkers for different FTD subtypes by proteomics”
Charlotte Teunissen, PhD
VU University Medical Center

2010 Award Recipients

Pilot Grants

“Early indicators and modifiers of age of onset of FTD”
Stephanie Cosentino, PhD
Columbia University

“Imaging the Role of Progranulin Interaction with Sortilin in Frontotemporal Lobar Degeneration”
Stephen Strittmatter, MD, PhD
Yale University

AFTD-ADDF Accelerating Drug Discovery for FTD

“CSF Biomarkers of FTLD-TDP and FTLD-Tau — A Multi-Center Study”
William Hu, MD
Emory University

“Fine-mapping and characterization of genetic biomarkers that facilitate the acceleration of drug discovery for frontotemporal dementias”
Allen Roses, MD
Duke University

“TDP-43 and tau as cerebrospinal fluid biomarkers to discriminate frontotemporal dementia subtypes”
Marcel Verbeek, PhD, MSc
Donders Institute for Brain, Cognition, and Behavior
Radboud University

“[18F]-THK523, a novel in vivo tau imaging agent”
Victor Villemagne, MD
Austin Health

2009 Award Recipients

Pilot Grant

“Resting-State functional MRI in presymptomatic mutation carriers of MAPT or PGRN mutation”
John van Swieten, MD, PhD
Erasmus Medical Center Rotterdam

AFTD Postdoctoral Fellowship

“TDP-43 Acetylation and its Link to Frontotemporal Dementia”
Todd Cohen, PhD
University of Pennsylvania

AFTD-ADDF Accelerating Drug Discovery for FTD

“Passive Immunotherapy for Frontotemporal Dementia”
Einar Sigurdsson, PhD
New York Universit

“Drug Discovery for Progranulin-Mediated Frontotemporal Lobar Degeneration”
Philip van Damme, MD, PhD
KU Leuven 

“Tau Clearance by Autophagy”
Haung Yu, PhD
Columbia University

2008 Award Recipients

Pilot Grants

“Insensitivity to Negative (Penalizing) Feedback for Inappropriate Behaviors in FTD Linked to Orbito-Frontal Dysfunction”
Mark Gluck, PhD
Rutgers University

“MicroRNA dysregulation in frontotemporal lobar degeneration”
Rosa Rademakers, PhD
Mayo Clinic Jacksonville

AFTD-ADDF Accelerating Drug Discovery for FTD

“A Pilot Clinical Trial of NAP (AL-108) for Corticobasal Degeneration and Frontotemporal Lobar Degeneration with Predicted Corticobasal Degeneration Pathology”
Adam Boxer, MD, PhD
UCSF 

“Hsp90 inhibitors in tauopathies: in vivo pre-clinical development”
Gabriela Chiosis, PhD
Memorial Sloan-Kettering Cancer Center 

“Frontotemporal Lobar Degeneration (FTLD) biomarker assays”
Virginia Y.-M. Lee, PhD
University of Pennsylvania 

2007 Award Recipients

Pilot Grants

“Gene identification in a novel Mendelian FTLD-MND locus”
Marc Cruts, PhD
University of Antwerp 

“Assessing the molecular genetics of TDP-43-related neurodegeneration using a Drosophila model”
Paul Taylor, MD, PhD
University of Pennsylvania 

AFTD-ADDF Accelerating Drug Discovery for FTD

“In vitro testing of new lysosomal modulatory drugs for reducing tau aggregates in a hippocampal slice model”
Ben Bahr, PhD
University of North Carolina at Pembroke

“Clearance of Pathological Tau Conformers”
Einar Sigurdsson, PhD
New York University 

“Sirtuins as modifiers of neurodegeneration in a mouse model of frontotemporal dementia”
Tara Spires-Jones, DPhil
Massachusetts General Hospital 

“Optimization of Pharmacokinetic and Pharmacodynamic Properties of a Small Molecule O-glycosylation Inhibitor for Treatment of Frontotemporal Dementia”
David Vocadlo, PhD
Simon Fraser University

2006 Award Recipients

Pilot Grant

“Generation of a Mouse Model of Familial FTD caused by Progranulin Mutations”
Blair Leavitt, MD & Ian Mackenzie, MD
Simon Fraser University & University of British Columbia 

2005 Award Recipients

Pilot Grant

“To study the ubiquitinated proteins that are found in the “inclusions” that characterize brain cells in FTLD-MND”
Eileen Biggio, MD
Northwestern University