For Researchers

Today’s research can lead to tomorrow’s breakthroughs. In this section, you’ll learn about research funding opportunities, new AFTD initiatives, and more.

Accelerating Drug Discovery for FTD

Through this program, AFTD, in partnership with the Alzheimer’s Drug Discovery Foundation (ADDF), seeks to advance and support innovative small molecule and biologic (antibodies, oligonucleotides, peptides, gene therapy) drug discovery programs for FTD.

Current funding priorities for this program include:

  • Lead optimization of novel disease-modifying compounds (e.g., medicinal chemistry refinement, in vitro ADME)
  • In vivo testing of novel compounds, biologics, or repurposed drugs in relevant animal models for pharmacokinetics, dose-range finding, target engagement, in vivo efficacy and/or preliminary rodent tolerability studies

Note: This program is not currently funding:

  • Target identification/validation
  • Assay development
  • High-throughput/high-content screening

Award Details

  • Duration: 1 year, with the possibility of follow-on funding.
  • Average award amount (USD): $100,000 – $150,000.
  • Application of funds: Funding through this program supports approved personnel costs, supplies (e.g., consumables, chemicals, animals), small non-durable equipment up to $2,500, consultants, and patient costs related to clinical trials.
    Funding is not provided for indirect costs/overhead, capital equipment, equipment service contracts, publication costs, or travel (unless pre-approved under special circumstances).

Who can apply?

U.S. and international investigators working at:

  • Academic medical centers and universities; nonprofits
  • Biotechnology companies (existing companies or new spinouts) that demonstrate a clear need for nonprofit funding. Funding is provided through mission-related investments (MRIs) that require return on investment based upon scientific and/or business milestones.

Academic-industry partnerships are strongly encouraged.

Timeline — 2019 Awards

  • May 2019: RFP posted
  • July 12, 2019: LOIs due
  • August 9, 2019: Invited full proposal due
  • December 2019-January 2020: Notification of awards

Download the 2018 Drug Discovery Request for Proposals.

LOIs are reviewed on a rolling basis and can be submitted at any time prior to the deadline.

Applications are reviewed by ADDF and an external Scientific Review Committee, including members of the AFTD Medical Advisory Council. Applications from biotechnology companies will also be reviewed by ADDF’s Business Advisory Board.

Contacts

For program-related inquiries, please contact:

For application submission inquiries, please contact:

Visit the ADDF website for additional information.