The FTD Disorders


Frontotemporal degeneration causes a group of disorders that are identified according to distinct clinical signs and symptoms, or specific pathology.

Subtypes of FTD are identified clinically according to the symptoms that appear first and most prominently.  Clinical diagnoses include behavioral variant FTD (bvFTD), primary progressive aphasia (PPA), and the movement disorders progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD).

At autopsy, these clinical conditions are typically caused by a form of frontotemporal lobar degeneration (FTLD) pathology related to the accumulation of one of the following proteins: tau (FTLD-tau), TDP-43 (FTLD-TDP) or FUS (FTLD-FUS), although these clinical conditions also may also be caused by unusual presentations of Alzheimer’s disease.

Use the links below to learn more about a specific diagnosis.

Behavioral variant FTD (bvFTD)
Corticobasal Syndrome
FTD with Motor Neuron Disease (FTD/MND)
Pick’s Disease
Nonfluent/agrammatic variant Primary Progressive Aphasia
Semantic variant Primary Progressive Aphasia
Progressive Supranuclear Palsy
Logopenic variant Primary Progressive Aphasia

Visit our Resources page to find out about supports you can access if you or a loved one is living with FTD.