Currently Recruiting Clinical Trials and Studies

FTD Clinical Trials

TitleRecruitmentTypeInterventionsConditionsURLCountry - Region
Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)RecruitingResearch StudyFTLD|Progressive Supranuclear Palsy (PSP)|Frontotemporal Dementia (FTD)|Corticobasal Degeneration (CBD)|PPA Syndrome|Behavioral Variant Frontotemporal Dementia (bvFTD)|Semantic Variant Primary Progressive Aphasia (svPPA)|Nonfluent Variant Primary Progressive Aphasia (nfvPPA)|FTD With Amyotrophic Lateral Sclerosis (FTD/ALS)|Amyotrophic Lateral Sclerosis (ALS)|Oligosymptomatic PSP (oPSP)|Corticobasal Syndrome (CBS)https://ClinicalTrials.gov/show/NCT02365922US - AL, CA, FL, IL, MD, MA, MN, MO, NY, NC, PA, TX. Canada - BC, ON
Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS)RecruitingResearch StudyFamilial Frontotemporal Dementiahttps://ClinicalTrials.gov/show/NCT02372773US - CA, FL, MA, MN, MO, NY, PA. Canada - BC
Phenotype, Genotype & Biomarkers in ALS and Related Disorders (CReATe)RecruitingResearch StudyAmyotrophic Lateral Sclerosis|Frontotemporal Dementia|Primary Lateral Sclerosis|Hereditary Spastic Paraplegia|Progressive Muscular Atrophy|Multisystem Proteinopathyhttps://ClinicalTrials.gov/show/NCT02327845US - CA, FL, IA, KS, TX, VA. Germany
Impact of Emotional Mimicry and Oxytocin on Frontotemporal DementiaRecruitingClinical trial - repurposed drugDrug: Intranasal oxytocin|Drug: Saline Nasal MistFrontotemporal Dementiahttps://ClinicalTrials.gov/show/NCT01937013Canada - ON
Open-Label Study of TRx0237 in Subjects With Alzheimer's Disease or Behavioral Variant Frontotemporal Dementia (bvFTD)Enrolling by invitationClinical trial - new drug follow upDrug: TRx0237Alzheimer's Disease|Behavioral Variant Frontotemporal Dementiahttps://ClinicalTrials.gov/show/NCT02245568136 study locations in U.S., Europe, Asia, and Australia
Clinical Utility of Flutemetamol in the Differential Diagnosis and Prognosis of Alzheimer's and Frontotemporal DementiaRecruitingResearch study - ImagingPET Imaging: [18F]-Flutemetamol injectionAlzheimer's Disease|Frontotemporal Dementia https://ClinicalTrials.gov/show/NCT02353949Switzerland
Evaluation of [18F]MNI-777 PET as a Marker of Tau Pathology in Subjects With Tauopathies Compared to Healthy SubjectsRecruitingResearch study - ImagingPET Imaging: [18F]-T807 injectionAlzheimer's Disease (AD)|Parkinson's Disease (PD)|Chronic Traumatic Encephalopathy (CTE)|Progressive Supranuclear Palsy (PSP)|Frontal Temporal Dementia (FTD)|Pick's Disease|Tauopathies https://ClinicalTrials.gov/show/NCT02103894US - CT
Study of the Neural Basis of Analogical ReasoningRecruitingResearch study - Intervention, non-invasiveDevice: transcranial magnetic stimulation|Other: MRI imaging|Other: EEG recording|Behavioral: Neuropsychological examinationFrontotemporal Dementia|Progressive Supranuclear Palsy|Healthy Subjectshttps://ClinicalTrials.gov/show/NCT02236832France
Natural History and Biomarkers of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Caused by the C9ORF72 Gene MutationRecruitingResearch study - biomarkersAmyotrophic Lateral Sclerosis| Frontotemporal Lobar Degeneration https://ClinicalTrials.gov/show/NCT01925196US - MD (NIH)
Characterization of Inclusion Body Myopathy Associated With Paget's Disease of Bone and Frontotemporal Dementia (IBMPFD)RecruitingResearch study - geneticsInclusion Body Myopathy With Early-onset Paget Disease and Frontotemporal Dementia|Paget Disease of Bone|Frontotemporal Dementia|Myopathy https://ClinicalTrials.gov/show/NCT01353430US - CA
Genetics of Familial and Sporadic ALSRecruitingResearch study - geneticsAmyotrophic Lateral Sclerosis|Familial Amyotrophic Lateral Sclerosis|Amyotrophic Lateral Sclerosis and Frontotemporal Dementia|Lou Gehrig's Disease|Motor Neuron Disease|Primary Lateral Sclerosis https://ClinicalTrials.gov/show/NCT00821132US - IL
Genetic Study of Familial and Sporadic ALS/Motor Neuron Disease, Miyoshi Myopathy and Other Neuromuscular DisordersRecruitingResearch study - geneticsAmyotrophic Lateral Sclerosis|Frontotemporal Dementia|PLS|Motor Neuron Disease|Lou Gehrigs Disease|Familial Disease|Amyotrophic Lateral Sclerosis, Sporadic|Muscular Dystrophy|Miyoshi Myopathy https://ClinicalTrials.gov/show/NCT01459302US - MA
Identification of New FTLD Genes (FTLD-Exome)RecruitingResearch study -geneticsFrontotemporal Lobar Degeneration https://ClinicalTrials.gov/show/NCT02363062France
Examination of the Earliest Symptoms and Biomarkers of FTLD MAPT Carriers (ESFTLD)RecruitingResearch study - biomarkersConfirmed MAPT mutation in at least one biologically-related family memberContact Gayathri Cheran (Study Coordinator): gc2646@cumc.columbia.eduUS - MI, NY, Ireland
Care Ecosystem: Navigating Patients and Families Through Stages of CareRecruitingResearch study - behavioral interventionBehavioral: Navigated careDementia|Alzheimer Disease|Dementia, Vascular|Lewy Body Disease|Frontotemporal Lobar Degeneration|Memory Disorders https://ClinicalTrials.gov/show/NCT02213458US - CA, NB
Efficacy of web-based social-cognitive interventions in right hemisphere stroke and frontotemporal dementiaRecruitingResearch study – behavioral interventionBehavioral: Web-based social-cognitive training exercisesFrontotemporal dementia|Right-sided cerebral hemisphere cerebrovascular accident https://clinicaltrials.gov/ct2/show/NCT02506036US-MD
Computational tools for early diagnosis of memory disorders (ProsKuopio)Enrolling by invitationResearch studyAlzheimer’s disease|Frontotemporal dementia|Vascular dementia|Mild cognitive impairment
https://clinicaltrials.gov/ct2/show/NCT02050464Finland
Tau PET imaging with [18F]-AV-1451 in subjects with MAPT mutationsEnrolling by invitationResearch study - imagingPET imaging: [18F]-AV-1451 injectionFrontotemporal lobar degeneration|Frontotemporal degeneration|Taopathies https://clinicaltrials.gov/ct2/show/NCT02676843US-NY
Predict to prevent frontotemporal lobar degeneration (FDT) and amyotrophic lateral sclerosis (PREV-DEMALS)RecruitingResearch study – imaging; biomarkersPET imaging: [18F]-FDG injection MRI imagingFrontotemporal lobar degeneration| Amyotrophic lateral sclerosis https://clinicaltrials.gov/ct2/show/NCT02590276France
Evaluation and characterization of behavioral disorders and dementias by the behavioral dysexecutive syndrome inventory (BDSI) (ISDC)RecruitingResearch study -epidemiologyFrontotemporal dementia|Primary progressive aphasia (semantic dementia) https://clinicaltrials.gov/ct2/show/NCT02819700France
Evaluation of [18F]MNI-815 as a Potential PET Radioligand for Imaging Tau Protein in the Brain of Patients With TauopathiesRecruitingResearch study: imagingPET imaging: [18F]MNI-815 injectionFrontotemporal dementia (FTD)|Progressive Supranuclear Palsy (PSP)|Cortical Basal Syndrome (CBS) https://clinicaltrials.gov/ct2/show/NCT02531360US-CT

PPA Clinical Trials

TitleRecruitmentTypeInterventionsConditionsURLCountry - Region
Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)RecruitingResearch studyFTLD|Progressive Supranuclear Palsy (PSP)|Frontotemporal Dementia (FTD)|Corticobasal Degeneration (CBD)|PPA Syndrome|Behavioral Variant Frontotemporal Dementia (bvFTD)|Semantic Variant Primary Progressive Aphasia (svPPA)|Nonfluent Variant Primary Progressive Aphasia (nfvPPA)|FTD With Amyotrophic Lateral Sclerosis (FTD/ALS)|Amyotrophic Lateral Sclerosis (ALS)|Oligosymptomatic PSP (oPSP)|Corticobasal Syndrome (CBS)https://ClinicalTrials.gov/show/NCT02365922US - AL, CA, FL, IL, MD, MA, MN, MO, NY, NC, PA, TX. Canada - BC, ON
Communication Bridge Speech Therapy Research StudyRecruitingResearch study - behavioral interventionBehavioral: Monthly Check-in SessionPrimary Progressive Aphasia|Alzheimer's Disease|Frontotemporal Dementiahttps://ClinicalTrials.gov/show/NCT02439853US - IL
Language in Primary Progressive AphasiaRecruitingResearch studyPrimary Progressive Aphasiahttps://ClinicalTrials.gov/show/NCT00537004US - IL
Characterisation of Primary Progressive AphasiasRecruitingResearch studyBehavioral: Behavioural testing|Other: MRI imaging; PET imaging, [18F]FDG injection|Genetic: Genetic screeningAphasia Primary Progressivehttps://ClinicalTrials.gov/show/NCT02297035France
tDCS intervention in primary progressive aphasiaRecruitingClinical trial – noninvasive interventionDevice: Active transcranial direct current stimulation (tDCS) + speech-language therapy; Sham stimulation + speech-language therapyPrimary progressive aphasia| Frontotemporal degeneration|Mild cognitive impairmenthttps://clinicaltrials.gov/ct2/show/NCT02606422US-MD
Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS)RecruitingResearch studyFamilial frontotemporal dementia (fFTD) https://clinicaltrials.gov/show/NCT02372773US - CA, FL, MA, MN, MO, NY, PA. Canada - BC
Communication bridge speech therapyRecruitingClinical trial – behavioral interventionBehavioral: ?Internet-based video-practice speech and language therapy; monthly check-in sessionPrimary progressive aphasia|Frontotemporal dementia https://clinicaltrials.gov/ct2/show/NCT02439853US - IL
Efficacy of web-based social-cognitive interventions in right hemisphere stroke and frontotemporal dementiaRecruitingResearch study – behavioral interventionBehavioral: Web-based social-cognitive training exercisesFrontotemporal dementia|Right-sided cerebral hemisphere cerebrovascular accidenthttps://clinicaltrials.gov/ct2/show/NCT02506036US-MD
Rehabilitation and prophylaxis of anomia in primary progressive aphasiaRecruitingResearch study - behavioral interventionBehavioral: phonological, orthographic, or no trainingPrimary progressive aphasia
Anomia
https://clinicaltrials.gov/ct2/show/NCT02675270US-DC
Natural History and Biomarkers of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Caused by the C9ORF72 Gene MutationRecruitingResearch study - biomarkersAmyotrophic Lateral Sclerosis|Frontotemporal lobar degenerationhttps://clinicaltrials.gov/ct2/show/NCT01925196US-MD
Preventing language decline in dementiaRecruitingResearch study – behavioral interventionBehavioral: Language therapyPrimary progressive aphasiahttps://clinicaltrials.gov/ct2/show/NCT02541097Canada-ON
Evaluation and characterization of behavioral disorders and dementias by the behavioral dysexecutive syndrome inventory (BDSI) (ISDC)RecruitingResearch study - epidemiologyFrontotemporal dementia| Primary progressive aphasia (semantic dementia)https://clinicaltrials.gov/ct2/show/NCT02819700France
Longitudinal multi-modality imaging in progressive apraxia of speechRecruitingResearch study - imagingPET imaging: [18F]-deoxyglucose injection MRI imagingPPA Non-fluent|Aphasia Apraxia of Speech Primary Progressive|Non-fluent?Aphasia|Primary Progressive Aphasiahttps://clinicaltrials.gov/ct2/show/NCT01818661US-MN
Study of the neural basis of analogical reasoning (ANALOG)RecruitingResearch study – noninvasive interventionDevice: transcranial magnetic stimulation Other: MRI imaging Other: EEG recording Behavioral: Neuropsychological examinationFrontotemporal Dementia|Progressive Supranuclear Palsy|Healthy Subjectshttps://ClinicalTrials.gov/show/NCT02236832France
Predict to prevent frontotemporal lobar degeneration (FDT) and amyotrophic lateral sclerosisRecruitingResearch study – imaging; biomarkersPET imaging: [18F]-FDG injection |MRI imagingFrontotemporal lobar degeneration| Amyotrophic lateral sclerosishttps://clinicaltrials.gov/ct2/show/NCT02590276France

PSP CBD Clinical Trials

TitleRecruitmentTypeInterventionsConditionsURLCountry - Region
Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)RecruitingResearch studyFTLD|Progressive Supranuclear Palsy (PSP)|Frontotemporal Dementia (FTD)|Corticobasal Degeneration (CBD)|PPA Syndrome|Behavioral Variant Frontotemporal Dementia (bvFTD)|Semantic Variant Primary Progressive Aphasia (svPPA)|Nonfluent Variant Primary Progressive Aphasia (nfvPPA)|FTD With Amyotrophic Lateral Sclerosis (FTD/ALS)|Amyotrophic Lateral Sclerosis (ALS)|Oligosymptomatic PSP (oPSP)|Corticobasal Syndrome (CBS)https://ClinicalTrials.gov/show/NCT02365922US - AL, CA, FL, IL, MD, MA, MN, MO, NY, NC, PA, TX. Canada - BC, ON
Multiple Ascending Dose Study of Intravenously Administered BMS-986168 in Patients With Progressive Supranuclear PalsyRecruitingClinical trial - new drugDrug: BMS-986168|Drug: PlaceboProgressive Supranuclear Palsyhttps://ClinicalTrials.gov/show/NCT02460094US - AL, CA, FL, MD, MN, NJ, NY, PA, TX
A 6 Month, Open-Label, Pilot Futility Clinical Trial of Oral Salsalate for Progressive Supranuclear PalsyRecruitingClinical trial - repurposed drugDrug: SalsalateProgressive Supranuclear Palsyhttps://ClinicalTrials.gov/show/NCT02422485US - CA
Safety Study of TPI-287 to Treat CBS and PSPRecruitingClinical trial - new drugDrug: TPI 287 2 mg/m2|Drug: TPI-287 20 mg/m2|Drug: Placebo|Drug: TPI-287 6.3 mg/m2Primary Four Repeat Tauopathies (4RT)|Corticobasal Syndrome (CBS)|Progressive Supranuclear Palsy (PSP)|Corticobasal Degeneration (CBD)https://ClinicalTrials.gov/show/NCT02133846US - AL, CA
Young Plasma Transfusions for Progressive Supranuclear PalsyRecruitingResearch study - new interventionOther: Fresh Frozen PlasmaProgressive Supranuclear Palsyhttps://ClinicalTrials.gov/show/NCT02460731US - CA
4 Repeat Tauopathy Neuroimaging InitiativeRecruitingResearch study - imagingMRI imagingProgressive Supranuclear Palsy|Corticobasal Degenerationhttps://ClinicalTrials.gov/show/NCT01804452US - CA
Evaluation of [18F]MNI-777 PET as a Marker of Tau Pathology in Subjects With Tauopathies Compared to Healthy SubjectsRecruitingResearch study - imagingPET imaging: [18F]T807 ([18F]MNI-777)Alzheimer's Disease (AD)|Parkinson's Disease (PD)|Chronic Traumatic Encephalopathy (CTE)|Progressive Supranuclear Palsy (PSP)|Frontal Temporal Dementia (FTD)|Pick's Disease|Tauopathieshttps://ClinicalTrials.gov/show/NCT02103894US - CT
Biomarkers in Parkinsonian SyndromesRecruitingResearch study - biomarkersOther: CSF, blood and urine sampling|Other: clinical measures of disease severity and progressionParkinsonian Syndromes|Parkinson's Disease|Multiple System Atrophy|Progressive Supranuclear Palsyhttps://ClinicalTrials.gov/show/NCT02114242France
Identifying Biomarkers of Parkinson's Disease Using Magnetic Resonance Imaging (MRI)RecruitingResearch study - imagingBrain imaging MRIParkinson's Disease (PD)|Parkinsonism|Progressive Supranuclear Palsy (PSP)|Multiple System Atrophy (MSA)https://ClinicalTrials.gov/show/NCT01888185US - PA
Magnetic Resonance Imaging in the Diagnosis of Parkinsonian SyndromesRecruitingResearch study - imagingBrain imaging MRIParkinson's Disease|Multiple System Atrophy|Progressive Supranuclear Palsy|Vascular Parkinsonismhttps://ClinicalTrials.gov/show/NCT02445469Spain
Foot Mechanical Stimulation for Treatment of Gait and Gait Related Disorders in Parkinson's Disease and Progressive Supranuclear Palsy.RecruitingResearch study - non-invasive interventionDevice: Foot Mechanical Stimulation (GONDOLA)Idiopathic Parkinson's Disease|Progressive Supranuclear Palsyhttps://ClinicalTrials.gov/show/NCT01815281Italy
Study of the Neural Basis of Analogical Reasoning (ANALOG)RecruitingResearch study - noninvasive interventionDevice: transcranial magnetic stimulation|Other: MRI imaging|Other: EEG recording|Behavioral: Neuropsychological examinationFrontotemporal Dementia|Progressive Supranuclear Palsy|Healthy Subjectshttps://ClinicalTrials.gov/show/NCT02236832France
PROgressive Supranuclear Palsy CorTico-Basal Syndrome Multiple System Atrophy Longitudinal Study UK (PROSPECT-M)RecruitingResearch studyProgressive Supranuclear Palsy (PSP)|Corticobasal Degeneration|Multiple System Atrophy (MSA)https://clinicaltrials.gov/ct2/show/NCT02778607UK
A Molecular Anatomic Imaging Analysis of Tau in Progressive Supranuclear PalsyRecruitingResearch study - imagingPET imaging: [18F]-AV-1451 injectionProgressive Supranuclear Palsyhttps://clinicaltrials.gov/ct2/show/NCT02605785US-MN
Evaluation of [18F]MNI-815 as a Potential PET Radioligand for Imaging Tau Protein in the Brain of Patients With TauopathiesRecruitingResearch study - imagingPET imaging: [18F]MNI-815 injectionProgressive Supranuclear Palsy (PSP)|Cortical Basal Syndrome (CBS)|Frontal Temporal Dementia (FTD)|Alzheimer's Disease (AD)
https://clinicaltrials.gov/ct2/show/NCT02531360US-CT