Research Publications

Below is a sampling of scientific papers that relate to FTD. They are listed by topic, with most recent article first. We deeply appreciate the efforts of all of the scientists around the globe who are working to better understand, more accurately diagnose and develop treatments for FTD. For a comprehensive list, we encourage you to go to PubMed (see link below) where you can search by author or keyword and download abstracts or full articles. If you know of a key paper that is not listed here, please contact AFTD with the information.

We are very fortunate to see a surge of recent articles about FTD and the related group of diseases. This signifies a growth in interest by doctors, labs, and clinical investigators to better understand these disorders. We have compiled and grouped by category a sampling of some recent articles that we think our families may find most informative. To learn more, you can find a comprehensive list of articles about FTD and other related diseases on PubMed. If you know of a paper that is not listed here, please contact AFTD with the information.

To find original scientific articles online:

PubMed, a service of the National Library of Medicine, National Institutes of Health, provides access to MEDLINE citations and includes links to many sites providing full text articles and other related resources. At PubMed Central (embed this link: http://www.pubmedcentral.nih.gov/search for Frontotemporal dementia, Primary progressive aphasia, Corticobasal degeneration, etc.

Note: For recent publications, the full article may not be accessible to the public.

General Review

Frontotemporal dementia.
Perry DC, Miller BL.
Semin Neurol2013 Sep;33(4):336-41. doi: 10.1055/s-0033-1359316. Epub 2013 Nov 14.

Young-onset dementia.
Kuruppu DK, Matthews BR.
Semin Neurol2013 Sep;33(4):365-85. doi: 10.1055/s-0033-1359320. Epub 2013 Nov 14.

Frontotemporal dementia.
Warren JD, Rohrer JD, Rossor MN.
BMJ 2013 347:14827. Doi:10.1136/bmj.f4827.Epub 6 August 2013.

Clinical, genetic and neuropathological features of frontotemporal dementia: an update and guide.
Pelicano Paulos J, Massano J.
Acta Med Port. 2013 Jul-Aug;26(4):392-401. Epub 2013 Aug 30.

Unravelling the mysteries of frontotemporal dementia.
Ghoshal N, Cairns NJ.
Mo Med. 2013 Sep-Oct;110(5):411-6. Review.

Progranulin: at the interface of neurodegenerative and metabolic diseases.
Nguyen AD, Nguyen TA, Martens LH, Mitic LL, Farese RV Jr.
Trends Endocrinol Metab. 2013 Dec;24(12):597-606. doi: 10.1016/j.tem.2013.08.003. Epub 2013 Sep 10.

Induced Pluripotent Stem Cells (iPSC)

Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency.
Lee WC, Almeida S, Prudencio M, Caulfield TR, Zhang YJ, Tay WM, Bauer PO, Chew J, Sasaguri H, Jansen-West KR, Gendron TF, Stetler CT, Finch N, Mackenzie IR, Rademakers R, Gao FB, Petrucelli L.
Hum Mol Genet. 2013 Nov 7.

RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention.
Donnelly CJ, Zhang PW, Pham JT, Heusler AR, Mistry NA, Vidensky S, Daley EL, Poth EM, Hoover B, Fines DM, Maragakis N, Tienari PJ, Petrucelli L, Traynor BJ, Wang J, Rigo F, Bennett CF, Blackshaw S, Sattler R, Rothstein JD.
Neuron. 2013 Oct 16;80(2):415-28. doi: 10.1016/j.neuron.2013.10.015.

Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC-derived human neurons.
Almeida S, Gascon E, Tran H, Chou HJ, Gendron TF, Degroot S, Tapper AR, Sellier C, Charlet-Berguerand N, Karydas A, Seeley WW, Boxer AL, Petrucelli L, Miller BL, Gao FB.
Acta Neuropathol. 2013 Sep;126(3):385-99. doi: 10.1007/s00401-013-1149-y. Epub 2013 Jul 9.

Diagnosis, Symptoms, etc.

A comparison of FDG-PET and blood flow SPECT in the diagnosis of neurodegenerative dementias: a systematic review.
Davison CM, O’Brien JT.
Int J Geriatr Psychiatry. 2013 Oct 9. doi: 10.1002/gps.4036. [Epub ahead of print]

Neuroimaging biomarkers of neurodegenerative diseases and dementia.
Risacher SL, Saykin AJ.
Semin Neurol. 2013 Sep;33(4):386-416. doi: 10.1055/s-0033-1359312. Epub 2013 Nov 14.

Behavioral symptoms related to cognitive impairment.
Dillon C, Serrano CM, Castro D, Leguizamón PP, Heisecke SL, Taragano FE.
Neuropsychiatr Dis Treat. 2013;9:1443-1455. Epub 2013 Sep 19. Review.

Caregiver Burden and Needs in Frontotemporal Dementia.

Diehl-Schmid J, Schmidt E-M, Nunnemann S, Riedl L, Kurz A, Förstl H, Wagenpfeil S, Cramer B.
J Geriatr Psychiatry Neurol  published online 31 July 2013

Therapeutic Interventions

A review of quality of life after predictive testing for and earlier identification of neurodegenerative diseases.
Paulsen JS, Nance M, Kim JI, Carlozzi NE, Panegyres PK, Erwin C, Goh A, McCusker E, Williams JK.
Prog Neurobiol. 2013 Nov;110:2-28. doi: 10.1016/j.pneurobio.2013.08.003. Epub 2013 Sep 11.

Memantine hydrochloride in the treatment of dementia subtypes.
Peng D, Yuan X, Zhu R.
J Clin Neurosci. 2013 Nov;20(11):1482-5. doi: 10.1016/j.jocn.2013.02.041. Epub 2013 Sep 13.

Oligonucleotide-Based Therapy for FTD/ALS Caused by the C9orf72 Repeat Expansion: A Perspective.
Fernandes SA, Douglas AG, Varela MA, Wood MJ, Aoki Y.
J Nucleic Acids. 2013;2013:208245. Epub 2013 Nov 17. Review.

 Genetics of FTD

The genetics of dementia.
Farlow JL, Foroud T.
Semin Neurol. 2013 Sep;33(4):417-22. doi: 10.1055/s-0033-1359313. Epub 2013 Nov 14.

Epigenetics of Alzheimer’s disease and frontotemporal dementia.
Veerappan CS, Sleiman S, Coppola G.
Neurotherapeutics. 2013 Oct;10(4):709-21. doi: 10.1007/s13311-013-0219-0.

The clinical and pathological phenotypes of frontotemporal dementia with C9ORF72 mutations.
Liu Y, Yu JT, Sun FR, Ou JR, Qu SB, Tan L.
J Neurol Sci. 2013 Dec 15;335(1-2):26-35. doi: 10.1016/j.jns.2013.09.013. Epub 2013 Sep 17.

Development and validation of pedigree classification criteria for frontotemporal lobar degeneration.
Wood EM, Falcone D, Suh E, Irwin DJ, Chen-Plotkin AS, Lee EB, Xie SX, Van Deerlin VM, Grossman M.
JAMA Neurol. 2013 Nov 1;70(11):1411-7. doi: 10.1001/jamaneurol.2013.3956.