Research Publications

Below is a sampling of scientific papers that relate to FTD. They are listed by topic, with most recent article first. We deeply appreciate the efforts of all of the scientists around the globe who are working to better understand, more accurately diagnose and develop treatments for FTD. For a comprehensive list, we encourage you to go to PubMed (see link below) where you can search by author or keyword and download abstracts or full articles. If you know of a key paper that is not listed here, please contact AFTD with the information.

We are very fortunate to see a surge of recent articles about FTD and the related group of diseases. This signifies a growth in interest by doctors, labs, and clinical investigators to better understand these disorders. We have compiled and grouped by category a sampling of some recent articles that we think our families may find most informative. To learn more, you can find a comprehensive list of articles about FTD and other related diseases on PubMed. If you know of a paper that is not listed here, please contact AFTD with the information.

To find original scientific articles online:

PubMed, a service of the National Library of Medicine, National Institutes of Health, provides access to MEDLINE citations and includes links to many sites providing full text articles and other related resources. At PubMed Central (embed this link: http://www.pubmedcentral.nih.gov/)  search for Frontotemporal dementia, Primary progressive aphasia, Corticobasal degeneration, etc.

Note: For recent publications, the full article may not be accessible to the public.

General

Leyton CE, Hodges JR. Frontotemporal dementias; Recent advances and current controversies. Ann Indian Acad Neurol. 2010 Dec; 13:S74-80.

Mohandas E, Rajmohan V. Frontotemporal dementia; An updated overview. Indian J Psychiatry. 2009 Jan; 51 Suppl 1:S65-9.

Rankin KP, Santos-Modesitt W, Kramer JH, et al. Spontaneous social behaviors discriminate behavioral dementias from psychiatric disorders and other dementias. J Clin Psychiatry. 2008 Jan;69(1):60-73.

Ratnavalli E. Progress in the last decade in our understanding of primary progressive aphasia. Ann Indian Acad Neurol. 2010 Dec;13(Suppl 2):S109-15.

Trojanowski JQ, Duff K, Fillit H, et al. New directions for frontotemporal dementia drug discovery. Alzheimers Dement. 2008 Mar;4(2):89-93.

Vossel KA, Miller BL. New approaches to the treatment of frontotemporal lobar degeneration. Curr Opin Neurol. 2008 Dec;21(6):708-16.

Walentas CD, Shineman DW, Horton AR, et al. An analysis of global research funding for the frontotemporal dementias; 1998-2008. Alzheimers Dement. 2011 Mar;7(2);142-50.

Diagnosis, Symptoms and Course of FTD

Blass DM, Rabins PV. Depression in frontotemporal dementia. Psychomatics. 2009 May-Jun;50(3):239-47.

Drubach DA, Rabinstein AA, Molano J. Free will, freedom of choice and frontotemporal lobar degeneration. Mens Sana Monogr. 2011 Jan;9(1):238-50.

Hu W, et al. “Novel CSF biomarkers for frontotemporal lobar degeneration with lesions immunoreactive to TDP-43 (FTLD-TDP)” AAN 2013; abstract 001.

Mendez MF, Shapira JS. The spectrum of recurrent thoughts and behaviors in frontotemporal dementia. CNS Spectr. 2008 Mar;13(3):202-8.

Rogalski E, Johnson N, Weintraub S, Mesulam M. Increased frequency of learning disability in patients with primary progressive aphasia and their first-degree relatives. Arch Neurol. 2008 Feb;65(2):244-8.

Rohrer JD, Guerreiro R, Vandrovcova J, et al. The heritability and genetics of frontotemporal lobar degeneration. Neurology. 2009 Nov 3;73(18):145-6.

Wittenberg D, Possin KL, Rascovsky K, et al. The early neuropsychological and behavioral characteristics of frontotemporal dementia. Neuropsychol Rev. 2008 Mar;18(1):91-102.

Chow TW. What are the different initial presentations of frontotemporal dementia? J Mol Neurosci. 2011 May 27.

Stopford CL, Thompson JC, Neary D, et al. Working memory, attention, and executive function in Alzheimer’s disease and frontotemporal dementia. Corex. 2010 Dec 21.

Therapeutic Intervention

Grand JH, Caspar S, Macdonald SW. Clinical features and multidisciplinary approaches to dementia care. J Multidiscip Healthc. 2011;4:125-47.

Jicha GA. Medical management of frontotemporal dementias: the importance of the caregiver in symptom assessment and guidance of treatment strategies. J Mol Neurosci. 2011 Jun 7.

Massimo L, Grossman M. Patient care and management of frontotemporal lobar degeneration. Am J Alzheimers Dis Other Demen. 2008 Apr-May;23(2):125-31.

Merrilees J, Klapper J, Murphy J, et al. Cognitive and behavioral challenges in caring for patients with frontotemporal dementia and amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2010 May 3; 11(3):298-302.

Merrilees J, Ketelle R. Advanced practice nursing: meeting the caregiving challenges for families of persons with frontotemporal dementia. Clin Nurse Spec. 2010 Sep-Oct; 24(5); 245-51.

Genetics of FTD

Kwiatkowski T. J., et al. Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis  Science 323, 1205 (2009)

Baker M, Mackenzie I.R., Pickering-Brown S.M. et al. Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. Nature, July 2006

Cruts M., Gijselinck I., van der Zee J. Null mutations in progranulin cause ubiquitinpositive frontotemporal dementia linked to chromosome 17q21. Nature, July 2006