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Grants Portfolio - Active Awards
AFTD-ADDF Accelerating Drug Discovery for FTD
TTBK1 inhibitors as new therapeutic approach for FTD and other related disorders
Ana Martinez, PhD | Ankar Pharmaceuticals
May 2023
$185,000
Selecting lead candidate REV-ERB agonist for the treatment of FTD
Robert Williams, PhD | Pelagos Pharmaceuticals
May 2023
$214,118
Discovery of selective LRP1 inhibitors to prevent tau uptake and spread
Kenneth Kosik, MD | University of California Santa Barbara
December 2021
$300,000
Development of PIKFYVE antisense oligonucleotides (ASO) treatment for FTD
Wen-Hsuan Chang, PhD | AcuraStem Inc.
May 2021
$165,000
Preclinical efficacy study for antibody therapy in C9orf72 FTD/ALS mice
Dieter Edbauer, MD | German Center for Neurodegenerative Diseases
December 2019
$300,000
Low-dose lithium for the treatment of behavioral symptoms in FTD
Edward Huey, MD | Brown University
2015
$532,335
AFTD-ADDF Diagnostics Accelerator
Judith Steen, PhD | Harvard Medical School
September 2020
$572,678 USD
Rodney Pearlman, PhD | Bluefield Project to Cure FTD
October 2019
$1,200,000 USD
FTD Biomarkers Initiative
Mapping neuroinflammation in frontotemporal lobar degeneration – development of a surrogate marker for early diagnosis and disease progression
Tammaryn Lashley, MD, PhD and Kerstin Sander MD | University College London
October 2022
Accelerating tau PET imaging through head to head comparison of novel radiotracers
Tammaryn Lashley, MD, PhD and Kerstin Sander MD | University College London
December 2018
$247,272
Cryo-electron microscopy of brain-derived TDP-43 filaments to rationally design PET ligands for FTD
Anthony Fitzpatrick, PhD | Columbia University Medical Center
March 2019
$150,000
Assessing poly(GP) proteins as clinical and pharmacodynamic biomarkers of C9ORF72-associated FTD
Leonard Petrucelli, PhD | Mayo Clinic Jacksonville
October 2019
$565,248
Targeting structural alterations of TDP-43 and other proteins to develop biomarkers for FTLD subtypes
Magdalini Polymenidou, PhD | University of Zurich, Switzerland
September 2019
$532,122
Digital Assessment Tools for FTD and ALS
Harmonizing remote smartphone assessments of cognition, behavior, and motor functioning across the spectrum of FTD and ALS
Adam Staffaroni | UCSF
2023
$350,000
Digital Measurements of Motor and Voice Functions in FTD
Ashkan Vaziri | BioSensics
2023
$399,999
Treat FTD Fund
Wave Life Sciences: A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 1b/2a Study of WVE-004 Administered Intrathecally to Patients with C9orf72-associated Amyotrophic Lateral Sclerosis (ALS) or Frontotemporal Dementia (FTD)
Anne-Marie Li-Kwai-Cheung | Wave Life Sciences
2022
$1,190,392
Clinical Trial of Nabilone for Neuropsychiatric Symptoms in Frontotemporal Dementia
Simon Ducharme, MD | McGill University
2021
$1,399,077
Evaluating the effects of GLP-1 analog, oral semaglutide, as a treatment for sporadic behavioral variant frontotemporal dementia (bvFTD)
Paul Edison, MD | Imperial College London
2021
$2,000,000
Dopaminergic Therapy for Frontotemporal Dementia Patients
Giacomo Koch, PhD | Saint Lucia Foundation
$602,800
Pilot Grants
PATHWAYS FOR HOPE
Aberrant protein condensation as a driver of neuroinflammation in ALS/FTD
Steven Boeynaems | Baylor College of Medicine
April 2023
$110,000
PATHWAYS FOR HOPE
Defining the role of TBK1 loss-of-function in FTD
Daniel Mordes | UCSF
April 2023
$110,000
WELL-BEING IN FTD
Social Network Neuromodulation in Behavioral Variant Frontotemporal Dementia
Alexandru Iordan | University of Michigan
April 2023
$110,000
WELL-BEING IN FTD
Positive Behaviour Support (PBS) for individuals with frontotemporal dementia: increasing service and family capacity through a mentoring and training model
Alinka Fisher, PhD | Finders University
April 2022
$60,000
Clinical Research Training Scholarship in FTD
Personalized HD-tDCS in Primary Progressive Aphasia
Tanav Popli | University of Michigan
2023
$150,000
Multimodal evidence of the role of Alzheimer’s disease pathology in corticobasal and progressive supranuclear palsy syndromes
Indira García Cordero, PhD | University of Toronto
2022
$150,000 USD ($75,000/year)
Mentor: Carmela Tartaglia
Holloway Postdoctoral Fellowships
Targeting TDP-43 aggregation as therapeutics for ALS/FTD
Marc Shenouda | University of Toronto
July 2023
$120,000
Virtual Reality Social Cognition Game for Preclinical Frontotemporal Dementia
Jackie Poos | Erasmus Medical Center
July 2023
$115,000
Investigating O-glycosylation modification in C9ORF72 FTD/ALS pathogenesis
Eric Anderson, PhD | University of Pittsburgh
$120,000 USD ($60,000/year)
Mentor: Udai Pandey, PhD
Deciphering the consequences of chromogranin A (CgA) depletion in tauopathy
Suborno Jati, PhD | University of California San Diego
$120,000 USD ($60,000/year)
Mentor: Renzo Mancuso
Long-read transcriptomics in FTLD-TDP to aid in the identification of novel biomarkers and mechanistic insights
Julia Faura Llorens, PhD | Vlaams Instituut voor Biotechnologie (VIB)
2022
$120,000 USD ($60,000/year)
Mentor: Rosa Rademakers
Indira García Cordero, PhD | University of Toronto
2021
Neuronal network dysfunction in neurodegenerative disease
Daniel Okobi, MD, PhD | University of California, Los Angeles
July 2021
$120,000 USD ($60,000/year)
Dissecting the molecular consequences of C9orf72 loss in lysosomal homeostasis and ALS-FTD disease pathogenesis
Hijai Regina Shin, PhD | University of California, Berkeley
July 2021
$120,000 USD ($60,000/year)
Modulating TDP-43-dependent loss of STMN2 in FTD
Matthew Nolan, PhD | Massachusetts General Hospital
July 2021
$120,000 USD ($60,000/year)
BASIC SCIENCE
A structural approach to rescuing C9orf72 haploinsufficiency in ALS/FTD
Ming-Yuan Su, PhD | The Regents of the University of California
July 2019
$110,000
CLINICAL RESEARCH
Identification of an RNA-based biomarker for FTD
Oriol Dols Icardo, PhD | Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau
January 2020
$110,000
Active AFTD Awards
Translational Research
AFTD-ADDF Accelerating Drug Discovery for FTD
AFTD-ADDF Diagnostic Accelerator
Digital Assessment Tools for FTD and ALS
Holloway Fellowships
Clinical Research Training Scholarship in FTD
Holloway Postdoctoral Fellowship