The FTD Disorders


Frontotemporal degeneration causes a group of disorders that are identified according to distinct clinical signs and symptoms, or specific pathology.

Subtypes of FTD are identified clinically according to the symptoms that appear first and most prominently.  Clinical diagnoses include behavioral variant FTD (bvFTD), primary progressive aphasia (PPA), and the movement disorders progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD).

At autopsy, these clinical conditions are typically caused by a form of frontotemporal lobar degeneration (FTLD) pathology related to the accumulation of one of the following proteins: tau (FTLD-tau), TDP-43 (FTLD-TDP) or FUS (FTLD-FUS), although these clinical conditions also may also be caused by unusual presentations of Alzheimer’s disease.

NewlyDxcoverAFTD has created a publication that helps individuals and families take a strategic approach to a diagnosis of FTD and prepare for the changes it brings – A Guide for Managing a New Diagnosis – The Doctor Thinks It’s FTD. Now What?.  If you are requesting more than 4 copies, please click here for our order form, which includes a $1/book charge to cover shipping costs.

Use the links to the right to learn more about a specific diagnosis.